Uncovering a secret room that a giant virus creates inside its host amoeba

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...
AZoLifeSciences on MSN

DeepCodon: A rare-codon–aware AI tool boosts protein expression in E. coli

A research team has developed DeepCodon, a deep learning–based codon optimization tool that significantly improves heterologous protein expression in Escherichia coli while preserving functionally ...
Nature

How viral RNAs escape a host mechanism that controls translation

This is a summary of: Liu. H. et al. Viral RNA blocks circularization to evade host codon usage control. Nature https://doi.org/10.1038/s41586-025-09809-y (2025).
The Scientist

Expanding the Genetic Alphabet

Living organisms synthesize a staggering variety of proteins by combining 20 amino acids into chains of any length and order. In the past, to expand protein diversity beyond the scope of these 20 ...

Unusual genetic code in Antarctic microbes yields rare amino acid

Researchers discover a unique genetic code in Antarctic archaea that encodes a rare amino acid, potentially advancing protein ...
eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
EurekAlert!

The secret room a giant virus creates inside its host amoeba

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...