In cell signaling, calcium is king. The flux of calcium ions across cell membranes regulates cellular activities from muscle contraction to neuron firing to immune cell function. A talk I saw here at ...

The regulation of intracellular calcium is pivotal in driving various cellular processes, including proliferation, apoptosis, migration and gene transcription. In cancer, aberrant calcium signalling ...

The researchers found that this process is triggered when a neuronal signal causes calcium to enter the dendrite through voltage-gated ion channel proteins, which are positioned at the contact sites.

Cerebral blood delivery depends on mechanisms such as electrical signaling, which propagates through capillary networks to upstream arterioles to deliver blood, and calcium signaling, which fine-tunes ...

The transition from single-celled organisms to multicellular life was a pivotal moment in evolutionary history, marking the emergence of complex communication systems that allow cells to coordinate ...

Exemplary Ca2+ signaling microdomains. Cartoon illustration of various microdomains featured in different types of cells, all being artificially integrated in a hypothetical single cell. (1) Cardiac ...

Plants have evolved sophisticated mechanisms to cope with environmental stressors including drought, nutrient deficiency, and extreme temperatures. Central to these adaptive responses is calcium ...

A new method exposes key details of the mechanism behind calcium signaling in prokaryotes for the first time. Working in a Listeria monocytogenes model, researchers from Umeå University (Sweden) led ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

A study published in Nature Communications examined the use of calcium carbonate nanoparticles (CNPs) to improve the activation and function of cytotoxic T lymphocytes (CTLs) in cancer immunotherapy.

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...