The reaction involves adding an organolithium anion to a source of a nitrogen-containing carbon stereocenter. This chemistry builds a crucial chiral center in verubecestat, a compound Merck has ...

As drug discovery places greater emphasis on practical execution and scalable delivery, flow chemistry is playing an increasingly important role across modern synthesis workflows. At the latest Viva ...

Researchers have developed a new process that uses microwave flow reaction and recyclable solid catalysts to efficiently hydrolyze polysaccharides into simple sugars. The developed device utilizes a ...

Optimizing chemical reactions and finding the best ways to scale them up to produce compounds for clinical testing and drug commercialization can be tedious, time-consuming, and expensive. To overcome ...

A simple diagram of the chemical process in the device developed by the research team. In their system, a solution of the disaccharide cellobiose (left) is passed through a sulfonated carbon catalyst ...