In vitro investigations of the interaction between IL-2 and IL-2 receptors, as well as antibody immunization and screening, need a series of structurally stable and high-affinity IL-2 receptor ...

The antibody’s novel mechanism of action is to bind precisely to IL-2 instead of IL-2 receptors. By binding only to the portion of IL-2 that binds to CD25, AU-007 prevents IL-2 from binding to ...

Image Credit: Sino Biological Inc. IL-2 performs its function by attaching to IL-2 receptors (IL-2R). Three subunits of the IL-2 receptor are available — α chain (CD25), β chain (CD122 ...

“The Phase 2 dose expansion data for our monoclonal antibody ... from binding to trimeric receptors on regulatory T cells while still allowing IL-2 to bind and expand effector T cells and ...

Roche's activity in this area is represented by RG6279, an anti-PD-1 antibody fused to an engineered ... mediated through the IL-2 alpha receptor. Foremost among those was Bristol-Myers Squibb ...

Given the known importance of duration and strength of T cell receptor (TCR ... Functional inactivation of IL-2 by neutralizing antibodies prevented the induction of IFNγ-producing T cells ...

Antibodies that interfere with IL-6 function Tocilizumab is a monoclonal antibody directed against the IL-6 receptor that has established benefit in RA both with regards to clinical efficacy and ...

Recent research has focused on the role of the IL-2 receptor in acute allograft rejection. T-cell proliferation, a central event leading to graft rejection, is triggered by the interaction of IL-2 ...

These findings suggest that KIR2DS2-positive (KIR2DS2+) natural killer (NK) cells could be an attractive therapeutic target ...