After a wild Week 18, the 2025-26 NFL regular season is complete and we turn our attention to the playoffs. Los Angeles Rams quarterback Matthew Stafford is the -135 betting favorite to win NFL MVP, the Seattle Seahawks are the Super Bowl favorites — and NFC's No. 1 seed — and the Denver Broncos are the No. 1 seed in the AFC.

If you're ready to put some action on this weekends slate, here is a preview of all of the opening betting lines for Wild Card weekend.

It was a super Saturday and so-so Sunday for oddsmakers in NFL Week 18. Patrick Everson reports on that and more.

The SportsLine Projection Model is high on the road team. It has the Colts covering the spread in 57% of simulations and winning outright in 34% to bring value as +455 underdogs. The model has the Over hitting in 65% of simulations.

Welcome to the New York Giants betting angle, Week 18 edition. It’s the last of these columns for this season, since Big Blue will once again be watching the NFL playoffs from a distance. Each week, I’m giving you my three favorite wagers for that week’s New York Giants game.

The Los Angeles Rams are the biggest favorites of the NFL Wild Card Round as they head to Carolina to take on the Panthers on Saturday afternoon. Los Angeles fi

Get the opening NFL Wild Card Weekend odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Jan. 10, 2026.

SportsLine expert Larry Hartstein breaks down how bettors and sportsbooks fared in Week 18 of the 2025 NFL season