This article was originally published on fansided.com as NFL Week 15 picks and predictions, straight-up and ATS: Bills-Patriots, Packers-Broncos lead huge slate.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 on a 50-35 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Can Trevor Lawrence continue his hot streak against the rival Colts? Will Derek Stingley Jr. get another pick-six? Our analysts provide bold predictions for Week 17 of the 2025 NFL season.

The NFL playoff picture continues to become clearer as Week 17 moves into the weekend. Houston clinched a playoff berth with a win on Dec. 27 against the LA Chargers. In the second game of the day, Baltimore stayed alive in the AFC North division race with a win at Green Bay.

The Colts have slim playoff hopes, while the Jaguars are trying to win the division. Motivation goes to the Jaguars. The Colts have a ton of major injuries and the defense is a mess. The Jacksonville offense is rolling and Trevor Lawrence will continue that here.