The skeleton undergoes continuous remodeling throughout life in response to diverse environmental stimuli. Osteoclasts, which are specialized cells on the bone surface, break down old bone tissue (in ...

Most existing treatments for pathological bone loss inhibit osteoclasts (bone-destroying cells) to limit bone degradation. However, by doing this, they also prevent bone formation since it is ...

Female ginseng has long been used in traditional Chinese medicine for osteoporosis treatment. A new compound that affects osteoclast formation has been derived from the plant Angelica sinensis, ...

During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a suppressive ...

The number of Americans stricken by a deadly and debilitating bone-thinning disease continues to climb. According to a 2004 Surgeon General's report, more than half of Americans age 50 and older are ...

Pharmacodynamic analysis of receptor tyrosine kinase (RTK) activity reveals differential target inhibition in skin and tumor in a phase I study of advanced colorectal cancer patients treated with ...

Osteoporosis, characterized by an imbalance in bone remodeling, is a growing health concern worldwide. Previous research has highlighted the role of osteogenic CpG oligodeoxynucleotide (iSN40) in ...

New research suggests that the problem of bone loss caused by microgravity conditions in space flight may be successfully treated using the time-tested drug melatonin. Melatonin increases the level of ...

Researchers have shown that glioblastoma can take over the skull marrow to dissolve bone and feed its own growth, suggesting ...