A team of researchers from the University of Queensland, La Trobe University and Monash University, all in Australia, has found evidence that suggests the evolutionary loss of a ryanodine receptor ...

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...

Overzealous calcium signaling and dysfunctional protein degradation occur early in Alzheimer’s disease pathogenesis. Now, new evidence links the two. Two recent papers support the hypothesis that, ...

(A) Schematic diagram of the experimental system that detects calcium release from the endoplasmic reticulum by each ryanodine receptor. (B) Isoflurane selectively activates RyR1 (mean ± standard ...

High-resolution images of the ryanodine receptor, a protein associated with calcium-related disease, reveal in unprecedented detail the locations of more than 50 mutations that cluster in disease ...

Since their effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general anesthesia in surgical operations. However, the mechanism of their anesthetic ...

The Nature Index 2026 Research Leaders reveal the leading institutions and countries/territories in the natural sciences, health sciences, applied sciences and social sciences, according to their ...