Class IV and class V viruses are single-stranded RNA (ssRNA viruses) in which the positive sense genome is translated into protein by host machinery, allowing viral reproduction. ssRNA class V viruses ...

Human SSB1 (single-stranded binding protein 1 [hSSB1]) was recently identified as a part of the ataxia telangiectasia mutated (ATM) signaling pathway. To investigate hSSBl function, we performed ...

An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.

Temporary protein-protein bonds are essential for processes including enzymatic reactions, antibody binding, and response to medication. Being able to accurately characterize these bonds is important ...

The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the proteins in a sample with increased sensitivity, reproducibility, and accessibility.

Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of ...