Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the difficulty of isolating ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...

BRCA1 and BRCA2 are genes that help prevent tumors from growing. If you inherit a change, or mutation, in these genes, they stop doing their jobs, and cancer can develop. In the United States, about 1 ...

The past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been diagnosed with breast cancer about the risk of recurrence and to guide ...

In patients with BRCA2-mutated mCSPC, treatment with Akeega significantly reduced the risk of radiographic progression or death by 54%. The Food and Drug Administration (FDA) has approved Akeega ® ...

Sometimes the most stunning advances in science are based on a hunch that a dedicated investigator just can’t shake. That was the case with Mary-Claire King, professor of genome sciences and of ...

"It's all about early detection," Mathew Knowles tells PEOPLE after battling breast cancer Mathew Knowles knows firsthand the power of early detection, which is why he urged his daughters, superstar ...

Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading RAD51 onto broken DNA strands. Normally, BRCA2 helps place RAD51 at DNA ...