How an enzyme activates its substrate for turnover is fundamental for catalysis but incompletely understood on a structural level. With redox enzymes one typically analyses structures of ...

We extend the classic Michaelis—Menten kinetics model of the enzyme-mediated conversion of substrate to product to situations in which the enzymes need to diffuse through the underlying structure to ...

Researchers imagine autonomous nanosized devices sailing through the blood stream, detecting molecular signs of disease or delivering drugs. Such devices will need nanomotors that can drive and steer ...

It is well known in physics and chemistry that equal charges repel each other, while opposite charges attract. It was long assumed that this principle also applies when enzymes -- the biological ...

The diagram below shows how an enzyme catalyses the breakdown of one substrate into two products.

Hydrophilic and hydrophobic molecules tend to avoid each other. But phosphoglycosyl transferases, enzymes that reside on bacterial cell membranes, can bring these odd couples together and catalyze ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they ...

Enzymes are also involved in the building up of chemical molecules elsewhere in the body. In an organism, the active site of each enzyme is a different shape. It is a perfect match to the shape of the ...