Note: This video is designed to help the teacher better understand the lesson and is NOT intended to be shown to students. It includes observations and conclusions that students are meant to make on ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

A paper titled "Functional implications of unusual NOS and SONOS covalent linkages found in proteins," by Matthew D. Lloyd, Kyle S. Gregory, and K. Ravi Acharya, from the University of Bath Department ...

BUFFALO, N.Y. and TALLAHASSEE, Fla. — New research shows that curium — one of the heaviest known elements — can be manipulated to a larger degree than previously thought. An international team ...

BUFFALO, N.Y. — One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent ...

From the salt in your kitchen to cutting-edge thermoelectrics, chemical bonding shapes the materials we rely on every day. Researchers are now uncovering how tweaking these bonds can unlock new ...

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

Researchers have found a new type of cross-link between amino acids in a protein (Nature 2021, DOI: 10.1038/s41586-021-03513-3). The intramolecular linkage is an N-O-S bridge formed by oxidizing the ...

Covalent organic frameworks (COFs) are versatile materials composed of interconnected organic molecules held together by covalent bonds. These frameworks can be constructed in two-dimensional or three ...

A research group has successfully demonstrated that carbon-carbon (C-C) covalent bonds expand and contract flexibly in response to light and heat. This unexpected flexibility of C-C bonds could confer ...