New insight into how xeroderma pigmentosum causative gene products ensure the accuracy of DNA repair
Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair ...
Xeroderma pigmentosum (XP) is a rare and devastating genetic disorder characterized by an inability to repair skin damage caused by ultraviolet (UV) light. As a result, patients with XP develop skin ...
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What is xeroderma pigmentosum? The rare genetic disorder that forces people to avoid sunlight
Affected populations: Xeroderma pigmentosum is a rare genetic disorder that makes people's skin extremely sensitive to the harmful effects of ultraviolet (UV) light. Both males and females can develop ...
A research group at Nagoya University in Japan, with collaborators, have used a new technology to identify a genetic abnormality that causes xeroderma pigmentosum (XP)-F, a skin disorder. The ...
New insight into how xeroderma pigmentosum causative gene products ensure the accuracy of DNA repair
XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...
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