Our Obsession With Statistical Significance Is Ruining Science

A century ago, two oddly domestic puzzles helped set the rules for what modern science treats as "real": a Guinness brewer ...
Open Heart

Adherence to the European Society of Cardiology hypertension guidelines over 12 years of follow-up in the Irish population

Background Hypertension is a significant risk factor for cardiovascular disease, dementia and chronic kidney disease (CKD).
Open Heart

Development and validation of a 10-year predictive model for cardiovascular and metabolic disease risk: insights from a large-scale health examination cohort

Objective To develop and validate a 10-year predictive model for cardiovascular and metabolic disease (CVMD) risk using ...
BMJ Open

Trajectories and predictors of spherical equivalent among multiethnic school-aged children in Southwest China: a 2.5-year cohort study

Objective The development of myopia is subject to individual genetic predisposition and environmental risk exposures. This ...
The Lancet

Effective sample size for individual risk predictions: quantifying uncertainty in machine learning models

Individual prediction uncertainty is a key aspect of clinical prediction model performance; however, standard performance metrics do not capture it. Consequently, a model might offer sufficient ...