Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein localization and function in living cells. These hybrid probes are constructed by diverse site-specific ...

Opioids have been essential in pain management, particularly when other analgesics prove insufficient, but their use is complicated by risks of addiction, tolerance, and a range of adverse effects.

KRASG12D, the most prevalent oncogenic mutation in KRAS-associated tumors, represents a highly sought-after drug target for cancer treatment. In this study, we explored a KRASG12D protein degradation ...

A concise, scalable total synthesis of (−)-bipinnatin J is disclosed. Commencing from inexpensive starting materials, this marine diterpenoid was fashioned through a convergent synthesis enabled by Ni ...

Compared to smaller or larger rings, seven- and eight-membered carbo- and heterocycles are typically nonplanar and exhibit greater conformational rigidity. This property alone can impart chirality to ...

3-Allylindoles constitute a key structural feature in many natural products and bioactive compounds. In this work, we developed a Mo-mediated reductive cyclization ...

Although the most commonly used method for enhancing a limit of detection (LoD) in immunoassay is adopting chemiluminescence (CL), the liquid form of CL substrates has hindered its use for rapid ...

Nanoaperture optical tweezers allow for trapping single proteins and detecting their conformational changes without modifying the protein, i.e., being free from labels or tethers. While past works ...

A wide variety of reactions are reported to be dramatically accelerated in aqueous microdroplets, making them a promising platform for environmentally clean chemical synthesis. However, to fully ...

No study has estimated the worldwide social (energy plus air pollution plus climate) costs of carbon capture and direct air capture. This study finds both substantially increase emissions and socia ...