The microscopic or individual dissociation constant describes the equilibrium of ligands binding to specific binding sites. Because we assume identical binding sites with no cooperativity, the …

Jan 30, 2023 · The dissociation constant is an immediate consequence of the law of mass action which describes equilibria in a more general way. The dissociation constant is also sometimes called …

Jun 23, 2025 · One of the most widely used metrics of binding affinity is the dissociation constant (KD). KD is defined as the concentration of ligand at which half of a partner’s binding sites are occupied …

Oct 1, 2024 · The dissociation constant (K d) is an equilibrium constant used universally in biochemistry and pharmacology to represent the binding affinity of substances (Guo et al., 2020).

Dissociation constants (K a and K b) are equilibrium constants that measure the strength of acids and bases. This lesson explores how K a and K b values relate to acid-base strength, hydronium ion …

Using kinetic interaction methods such as surface plasmon resonance and bilayer interferometry, the results contain more information than the equilibrium dissociation constant alone.

The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the drug-receptor. Thus, a variety of analytical methods have been established to determine the KD …

Glossary of Pharmacology Equilibrium dissociation constant (K d) Definition: A measure of the tendency of a larger complex to separate (dissociate) into its smaller parts. For example, when a protein …

Dec 29, 2017 · koff is the rate constant of dissociation. Units for k off are units of [DR] over time. Kd is the dissociation constant. This is the constant that describes the drug/receptor interactions at …

The dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls …