Mdm2 - Wikipedia
Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. The human …
Pathology Outlines - MDM2
Nov 25, 2020 · MDM2 amplification and overexpression in tumors is associated with radiation, chemotherapy, tyrosine kinase inhibitor and immune checkpoint inhibitor resistance (Cancer …
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The Medical Device Manufacturing Multiplier (MDM2) is a consortium of companies, institutions and statewide organizations collaborating to develop Greater Phoenix into a premier medical …
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
We herein summarize the research efforts to discover and develop MDM2 inhibitors, focusing on those that induce MDM2 degradation and exert anticancer activity, regardless of the p53 …
Structure and function of MDM2 and MDM4 in health and disease
MDM2 and MDM4 exhibit high structural resemblance, encoding proteins with ~32% identity and ~90% similarity. MDM2 contains 12 exons, whereas MDM4 has 11 exons; MDM2 encodes at …
MDM2 Gene - GeneCards | MDM2 Protein | MDM2 Antibody
Nov 14, 2025 · Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in …
The MDM2 Gene: Its Function and Role in Cancer Development
The MDM2 gene, also known as the MDM2 proto-oncogene, provides the blueprint for producing the MDM2 protein. This protein functions primarily as an E3 ubiquitin ligase, an enzyme that …
The roles and regulation of MDM2 and MDMX: it is not just …
In this review, Klein et al. discuss the p53-independent roles of MDM2 and MDMX. First, they review the structural and functional features of MDM2 and MDMX proteins separately and …
MDM2 Implications for Potential Molecular Pathogenic Therapies …
May 24, 2023 · Murine double minute 2 (MDM2, gene name MDM2) is an oncogene that mainly codes for a protein that acts as an E3 ubiquitin ligase, which targets the tumor suppressor …
MDM2- an indispensable player in tumorigenesis - Springer
Jun 14, 2023 · The MDM2 reprograms many biological processes that support malignant transformations e.g., cell growth, angiogenesis, metabolism, apoptosis evasion, and …