In medicinal chemistry and molecular biology, a pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological …

In other terms, “a pharmacophore is the arrangement of a molecule’s characteristics that are accountable for a biological effect.” A pharmacophore is formed by a set of characteristics …

Pharmacophore approaches represent one of the most interesting tools developed, by defining the molecular functional features needed for the binding of a molecule to a given receptor, and …

Jul 24, 2025 · A pharmacophore is a fundamental concept in the pursuit of new medicines, acting as a three-dimensional blueprint that describes the specific features a molecule must possess …

Jun 10, 2025 · The pharmacophore is responsible for the molecular recognition between the drug and its target, enabling the drug to bind selectively to its intended target. The pharmacophore …

May 21, 2025 · At its core, a pharmacophore is an abstract representation of molecular features necessary for a compound to interact with a specific biological target, such as a protein …

Pharmacophores are key molecular features that drive drug-target interactions. They represent the essential 3D arrangement of chemical groups responsible for a compound's biological …

Apr 18, 2023 · The pharmacophore concept was first put forward as a useful picture of drug interactions almost a century ago, and with the rise in computational power over the last few …

In general terms, a pharmacophore is best defined as the arrangement of those substructures or functional groups in an active compound that are crucial for its activity.

By comparing the 3D features of the two molecules, one can derive a pharmacophore model for aldose reductase inhibition. The pharmacophore consists of an acidic proton located at a …