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3:13
YouTube
Onkoview
BCR-ABL1 and the Philadelphia chromosome - Part 2: The Philadelphia chromosome
The Philadelphia chromosome, which is found in leukemic cells in more than 90% of all patients with chronic myeloid leukemia (CML), results from a translocation between chromosome 9 and chromosome 22. On the Philadelphia chromosome, the 5’ end of the gene BCR is fused to the major 3’ part of the gene ABL1. The amplification of the fused ...
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